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Bioactive molecules and the antidiabetic efficacy of Memecylon randerianum — an ethnomedicinal plant from the Western Ghats

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Title Bioactive molecules and the antidiabetic efficacy of Memecylon randerianum — an ethnomedicinal plant from the Western Ghats
 
Creator Lakshmi, MV
Swapna, TS
 
Subject Antidiabetic
Cosmosiin
Glucose uptake assay
HR-LCMS-QTOF
Malabar Memecylon
 
Description 849-857
Diabetes is one of the most chronic diseases and a leading cause of death even though it is preventable. There are
multiple therapeutic strategies like daily intake of drugs, insulin treatment and islet transplantation to manage severe diabetic
complications. But the plant based therapy with regular exercise can improve diabetic control with reduced medication. The
Malabar Memecylon, Memecylon randerianum S.M. Almeida & M.R. Almeida, is a medicinal shrub widely distributed in
the Western Ghats of Kerala. Leaves are the most utilized plant part in traditional medicine. In vitro antidiabetic activity and
HR-LCMS-QTOF analysis of the leaves, along with the screening of phytochemicals, has been executed in the present
investigation. The methanolic extract showed the highest presence of phytochemicals such as flavonoids, tannins, saponins
etc. The quantitative screening revealed that saponins (211.16±1.9 mg/g) and flavonoids (209.74±2.12 mg/g) were highly
concentrated, and the leaf extract showed significant dose-dependent inhibition on α-amylase and α- glucosidase. The
glucose uptake in L6 cell lines was found to be increased by 25% compared to untreated cells (control) at 100 μg/mL sample
concentration. HR-LCMS-QTOF analysis detected nine major compounds and showed that leaves of the plant could be used
as an effective therapeutic agent against the most common type 2 diabetes.
 
Date 2021-12-02T06:41:11Z
2021-12-02T06:41:11Z
2021-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58571
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.59(12) [December 2021]