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Evaluation of health status of <em>Oreochromis niloticus</em> (L.) based on brain optic tectum morphopathology

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Title Statement Evaluation of health status of <em>Oreochromis niloticus</em> (L.) based on brain optic tectum morphopathology
 
Added Entry - Uncontrolled Name Samanta, Palas ; Department of Environmental Science, Sukanta Mahavidyalaya, University of North Bengal, West Bengal, India
Ghosh, Apurba Ratan
 
Uncontrolled Index Term Adverse outcome pathways; Almix and Excel Mera 71; Brain; Herbicides; Neurotoxicity; Nile tilapia
 
Summary, etc. <em>Oreochromis niloticus</em> (L.) health status was evaluated based on brain optic tectum morphopathology. O. niloticus was exposed to sub-lethal Almix (66.67 mg/L) and Excel Mera 71 (17.2 mg/L) concentrations for 30 d. Results revealed that herbicides exposure caused different morphological changes in brain optic tectum. Almix treatment showed comparatively higher morphological changes compared with Excel Mera 71. The mean assessment value (MAV) showed significantly higher (p &lt; 0.0001) value in Almix (4.36±0.09) and Excel Mera 71 (3.60±0.09) exposure, in comparison with control fish (0.09±0.02). Stratum album centrale (SAC) and stratum periventriculare (SPV) were most affected layer compared with others. The observed morphological alterations revealed impaired visual, sensory and motor functions, which ultimately alters brain physiology. In particularly, the existence of necrosis in neural cells, loss of Nissl substances, gliosis and vacuole formations under Almix and Excel Mera 71 exposure indicated neurotoxic nature of these herbicides. However, higher prevalence under Almix treatment indicated higher neurotoxic potential than Excel Mera 71. Therefore, the results presented here are highly significant to toxicologist considering its neurotoxic property. Finally, further studies are needed to explore detailed mode of action of neurotoxicity for adverse outcome pathways (AOP) development at molecular level.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-12-02 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/57834
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 12 (2021): IJEB [DECEMBER 2021]
 
Language Note en