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Screening of antibacterial and cytotoxicity of the copper (II) complexes of N-donor chelating ligand

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Title Screening of antibacterial and cytotoxicity of the copper (II) complexes of N-donor chelating ligand
 
Creator Devi, A Bimolini
Devi, M Damayanti
Surbala, Laishram
 
Subject Antibacterial activity
Copper (II) complex
Cytotoxicity
Disc diffusion assay
MTT assay
 
Description 582-589
Copper (II) complexes, namely dichloromono(1-amidino-O-ethylurea)copper (II), (1) and bis(1-amidino-O-ethylurea)copper
(II) bromide, (2) were synthesized and characterized. The antibacterial screening of complexes 1 and 2 was performed along
with their corresponding metal salts (CuCl2.2H2O) and (CuBr2), and ligand (dicyandiamide), against two human urinary
pathogenic bacterial strains, Escherichia coli and Proteus mirabilis, by the disc diffusion method. All test compounds, except
ligand have shown significant antibacterial activities on both bacterial strains. Their antibacterial effectiveness increased in a
dose dependent manner, whereas their ability to inhibit the growth of both bacterial species decreased as their incubation time
increased. The activity of complex 1 was found to be greater than its metal salt, while that of complex 2 was lower than the
corresponding metal salt on both bacterial species. The in-vitro cytotoxic screening of complexes 1 and 2 was also assessed
against human cervical adenocarcinoma cancer (HeLa) cell line using the MTT assay. Both complexes 1 and 2 have displayed
cytotoxic effect in a dose-dependent manner with IC50 values of 59.64±6.68 µg/mL and 62.85±0.39 µg/mL, respectively.
Overall, the highest antibacterial and cytotoxic activity of the present work is provided by complex 1.
 
Date 2021-12-07T05:09:38Z
2021-12-07T05:09:38Z
2021-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/58596
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.58(6) [December 2021]