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Antioxidative potential and anticancer activity of Elaeagnus caudata (Schltdl) against Type-II human lung adenocarcinoma, A549 cells via caspase-mediated apoptotic cell death

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Title Antioxidative potential and anticancer activity of Elaeagnus caudata (Schltdl) against Type-II human lung adenocarcinoma, A549 cells via caspase-mediated apoptotic cell death
 
Creator Nghakliana, F
Lalmuansangi, C
Zosangzuali, Mary
Lalremruati, Marina
Zothansiama
 
Subject Anti-cancer
Antioxidant
Apoptosis
DNA damage
Elaeagnus caudata
 
Description 543-556
This study investigates the phytochemical composition, anti-oxidative potential and anti-cancer activity of silverberry
Elaeagnus caudata. The aqueous extract of E. Caudata has higher phenolic content (259.32 ± 5.18 mg GAE/g) and
flavonoid content (1869.25 ± 25.9 mg quercetin equivalent/g) than the methanolic extract. The aqueous extract possessed
higher scavenging activities than the methanolic extract for 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anions (O2•−)
and 2, 2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) with IC50 of 61.48 ± 1.06 μg/mL, 335.7 ± 0.61 μg/mL,
and 372.2 ± 16.17 μg/mL, respectively. Consistently, the aqueous extract was found to exhibit higher total reducing power
than the methanolic extract as well as standard ascorbic acid. The extracts were also analysed for their anti-haemolytic
activity and inhibitory effect on lipid peroxidation in an ex-vivo condition using mice erythrocyte and liver, respectively.
The aqueous extract of E. caudata showed higher inhibitory activities against hemolysis and lipid peroxidation with an
inhibition rate of 80.77% and 81.58%, respectively. E. caudata also induced cell death in A549 cells in a dose and time
dependent manner and increased the level and activities of antioxidants, while decreasing the lipid peroxidation (LPO) level
in the A549 cells. Induction of DNA damage and elevation of caspase-6 activity in A549 cells following E. caudata
treatment provide an insight into apoptosis based anti-cancer activities of E. caudata.
 
Date 2021-12-07T06:07:04Z
2021-12-07T06:07:04Z
2021-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/58600
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.58(6) [December 2021]