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Synthesis, antioxidant and antibacterial activities of quinoline incorporated 2,4,5trisubstituted imidazole derivatives

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Title Synthesis, antioxidant and antibacterial activities of quinoline incorporated 2,4,5trisubstituted imidazole derivatives
 
Creator Somashekara, B
Vijayakumar, G R
 
Subject 2-Chloroquinoline
2-hydroxyquinoline
antioxidant
antibacterial
 
Description 1601-1606
A series of quinoline incorporated 2,4,5-trisubstituted imidazole derivatives (4a-h and 5a-f) have been synthesized. The
structures of the synthesized compounds have been established by FT-IR, 1H NMR and mass spectral analysis. The prepared
compounds have been evaluated for their in vitro antioxidant activity by DPPH method and antibacterial activity against
Bacillus subtilis, Escherichia coli, Bacillus megaterium and Salmonella typhi bacterial strains at 500 µg/mL concentration.
The compounds 4a, 4e and 4d exhibit good antioxidant activity. Among the synthesized compounds, 4a has shown
significant antibacterial activity against all the three tested microorganisms.
 
Date 2021-12-15T10:33:16Z
2021-12-15T10:33:16Z
2021-12
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58606
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(12) [December 2021]