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Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives

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Title Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives
 
Creator Yardily, A
Shahana, M Fathima
Johnson, Jino
Lindry, Shijula
Reji, T F Abbs Fen
 
Subject Dendrodoine
benzothiazoles
anti-bacterial activity
anti-proliferative activity
anti-oxidant activity
DNA cleavage
 
Description 1621-1628
A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have
been synthesized. They have been characterized by elemental analysis, IR, 1H and 13C NMR and mass spectral techniques.
All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial
activity. Among these (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone is more
active. Moreover, the compound 3d shows promising antioxidant activity activity. The compounds have been further
evaluated for their potential for DNA cleavage and two compounds completely cleaved DNA. Two of the compounds have
been evaluated for their anti-proliferative activity against breast cancer cell lines. The IC50 value of the compound (4-amino2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
against the cell line MCF-7 is found to be
10 µg/mL. Four compounds have been docked towards 5077 receptor protein. Molecular docking shows very good
interaction with protein. In this (4-amino-2-(4-methoxyphenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone
has the highest binding interaction with the protein.
 
Date 2021-12-15T10:40:44Z
2021-12-15T10:40:44Z
2021-12
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58608
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(12) [December 2021]