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Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives

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Title Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives
 
Creator Arshad, Mohammad
Beg, Md Amjad
Bhat, Abdul R
Athar, Fareeda
 
Subject Synthesis
1,3,4-oxadiazoline
antimicrobial activity
MTT-assay
 
Description 1636-1651
Anovel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence
on in vitro growth of microbes causing the microbial contagion. In vitro antimicrobial activity has been performed against
the Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis) which are Gram-negative (Gram-ve) and Staphylococcus
aureus (S. aureus) and Staphylococcus epidermidis (S. epidermis) which are Gram-positive (Gram+ve) by using disk
diffusion method. The minimum inhibitory concentration (MIC) has been distinguished by employing the double dilution
method. The result of percent inhibition area/µg of the compounds has been differentiated with the standard drug
“Ciprofloxacin”. Several compounds portray excellent activity as compared to the standard drug Ciprofloxacin while some
of them presented a considerable zone of inhibition. The evaluated compounds for cytotoxicity effects via Human
hepatocellular carcinoma (HepG2) cell line by MTT-assay and findings reveal that the experimental compounds display a
viability of ≥80% at 100 µM. In molecular docking studies, the 1,3,4-oxadiazoline derivatives demonstrate the ligandreceptor
interaction with amino acids which exist on the active sites of the peptide deformylase and the 1,3,4-oxadiazoline
derivatives exhibit their antibacterial potential as peptide deformylase inhibitors.
 
Date 2021-12-15T11:07:53Z
2021-12-15T11:07:53Z
2021-12
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/58610
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC-B Vol.60B(12) [December 2021]