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<p><strong>Synthesis, Characterization, Antimicrobial, Anti-Diabetic, Anti-Inflammatory and Anti-Cancer studies of Schiff Base metal(II) complexes derived from </strong><strong>4-hydroxy-3,5 dimethoxybenzaldehyde and 3-aminoquinoline</strong></p>

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Title Statement <p><strong>Synthesis, Characterization, Antimicrobial, Anti-Diabetic, Anti-Inflammatory and Anti-Cancer studies of Schiff Base metal(II) complexes derived from </strong><strong>4-hydroxy-3,5 dimethoxybenzaldehyde and 3-aminoquinoline</strong></p>
 
Added Entry - Uncontrolled Name KARTHIK, SOMASUNDARAM ; DEPARTMENT OF CHEMISTRY, KANDASWAMI KANDAR'S COLLEGE,
GOMATHI, THULASIMANI
VEDANAYAKI, SUBRAMANIAM
No
 
Uncontrolled Index Term Bio inorganic chemistry
Schiff base, anti-inflammatory, anti-diabetic, anticancer
 
Summary, etc. <p>The new Schiff base ligand (E)-2,6-dimethoxy-4-((quinolin-3-ylimino)methyl )phenol (HL) and its Cu(II), Co(II), Ni(II) and Zn(II) metal complexes were synthesized and characterized by various spectroscopic (UV-vis, IR, NMR), SEM, Mass and magnetic susceptibility measurement. The ligand (HL) was synthesized by condensation of 4-hydroxy-3,5-dimethoxybenzaldehyde and 3-aminoquinoline. On the basis of electronic spectral data and magnetic susceptibility measurement the tetrahedral geometry has been proposed for all the complexes. The ligand and metal complexes have been screened for their antimicrobial activities against bacteria (<em>Staphylococcus aureus, Escherichia coli)</em> and antifungal activity against the fungi (<em>Candida albicans)</em>. Further the ligand and its Cu(II) complex was also screened for anticancer activity on human cancer cell lines such as breast (MCF7) by MTT assay method . Interestingly, Cu(II) complex shows better anticancer activity than the free schiffbase ligand . The<em> in vitro </em>anti-inflammatory and anti-diabetic activities of the ligand and Cu(II)<sup> </sup>complex were studied. The Cu(II)<sup> </sup>complex show higher inhibition activity than that of the free ligand.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-12-15 12:57:38
 
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http://op.niscair.res.in/index.php/IJCA/article/view/52780
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 11 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/52780/465571158
 
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