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<p class="Affiliation"><a name="_GoBack"></a><span>Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives</span></p><br /><br />

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Title Statement <p class="Affiliation"><a name="_GoBack"></a><span>Synthesis, structure elucidation and antibacterial screening of some novel 1,3,4-oxadiazoline derivatives</span></p><br /><br />
 
Added Entry - Uncontrolled Name Arshad, Mohammad ; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110 025, India College of Medicine Aldawadmi Shaqra University, Kingdom of Saudi Arabia
Beg, Md Amjad; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110 025, India
Bhat, Abdul R; Department of Chemistry, Sri Pratap College, Cluster University Srinagar 190 001, India
Athar, Fareeda ; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110 025, India
to UGC (F. No. 41-236/2012) and UGC MANF scheme wide letter no. F.40-65(C/M)/2009(SA-III/MANF)
 
Uncontrolled Index Term Synthesis, 1,3,4-oxadiazoline, antimicrobial activity, MTT-assay
 
Summary, etc. <p style="text-align: justify;">Anovel sequence of 1,3,4-oxadiazoline derivatives has been synthesized with an endeavour to explore their consequence on <em>in vitro</em> growth of microbes causing the microbial contagion. <em>In vitro </em>antimicrobial activity has been performed against the <em>Escherichia coli </em>(<em>E. coli</em>) and <em>Proteus mirabilis</em><em> </em>(<em>P. mirabilis</em>) which are Gram-negative (Gram-ve) and <em>S</em><em>taphylococcus aureus</em> (<em>S</em><em>. aureus</em>) and <em>S</em><em>taphylococcus epidermidis</em><em> </em>(<em>S</em><em>. epidermis</em>) which are Gram-positive (Gram+ve) by using disk diffusion method. The minimum inhibitory concentration (MIC) has been distinguished by employing the double dilution method. The result of percent inhibition area/µg of the compounds has been differentiated with the standard drug “Ciprofloxacin”. Several compounds portray excellent activity as compared to the standard drug Ciprofloxacin while some of them presented a considerable zone of inhibition. The evaluated compounds for cytotoxicity effects <em>via </em>Human hepatocellular carcinoma (HepG2) cell line by MTT-assay and findings reveal that the experimental compounds display a viability of ≥80% at 100 µM. In molecular docking studies, the 1,3,4-oxadiazoline derivatives demonstrate the ligand-receptor interaction with amino acids which exist on the active sites of the peptide deformylase and the 1,3,4-oxadiazoline derivatives exhibit their antibacterial potential as peptide deformylase inhibitors.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-12-20 11:23:07
 
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http://op.niscair.res.in/index.php/IJCB/article/view/33534
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 12 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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