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<p>Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives</p><br />

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Title Statement <p>Design, synthesis, characterization, bio-molecular docking studies, and biological activity of (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d] thiazol-2-yl)methanone derivatives</p><br />
 
Added Entry - Uncontrolled Name Yardily, A ; Department of Chemistry and Research Centre, Scott Christian College (Autonomous) Nagercoil 629 003, India
Shahana, M Fathima; Department of Chemistry and Research Centre, Scott Christian College (Autonomous) Nagercoil 629 003, India
Johnson, Jino ; Department of Chemistry and Research Centre, Scott Christian College (Autonomous) Nagercoil 629 003, India
Lindry, Shijula ; Department of Chemistry and Research Centre, Scott Christian College (Autonomous) Nagercoil 629 003, India
Reji, T F Abbs Fen; Department of Chemistry and Research Centre, Nesamony Memorial Christian College, Marthandam 629 165, India
Nil
 
Uncontrolled Index Term Dendrodoine, benzothiazoles, anti-bacterial activity, anti-proliferative activity, anti-oxidant activity, DNA cleavage  
 
Summary, etc. <p style="text-align: justify;">A series of novel (4-amino-2-(aryl/alkylamino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone compounds have been synthesized. They have been characterized by elemental analysis, IR, <sup>1</sup>H and <sup>13</sup>C NMR and mass spectral techniques. All the synthesized compounds have been screened for their antibacterial potential and show significant antibacterial activity. Among these (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone is more active. Moreover, the compound <strong>3d</strong> shows promising antioxidant activity activity. The compounds have been further evaluated for their potential for DNA cleavage and two compounds completely cleaved DNA. Two of the compounds have been evaluated for their anti-proliferative activity against breast cancer cell lines. The IC<sub>50</sub> value of the compound (4-amino-2-(4-chlorophenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone against the cell line MCF-7 is found to be 10 µg/mL. Four compounds have been docked towards 5077 receptor protein. Molecular docking shows very good interaction with protein. In this (4-amino-2-(4-methoxyphenyl)amino)thiazol-5-yl)(6-methylbenzo[d]thiazol-2-yl)methanone has the highest binding interaction with the protein.</p><p style="text-align: justify;"> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-12-20 11:23:07
 
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http://op.niscair.res.in/index.php/IJCB/article/view/33651
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 60, ##issue.no## 12 (2021): Indian Journal of Chemistry- Section-B, (IJCB)
 
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http://op.niscair.res.in/index.php/IJCB/article/download/33651/465510965
 
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