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Identifying clinically significant novel drug candidate for highly prevalent Alzheimer's disease

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Title Identifying clinically significant novel drug candidate for highly prevalent Alzheimer's disease
 
Creator Ali L, Benazir
A, Subramani
T, Baskar
Shabeer, T K
 
Subject ADME
Lipinski rule
Bioavailability
Curcumin-schiff base
Molecular simulation
Alzheimer’s disease
 
Description 618-623
Pharmacokinetics is very important in target validation and in shifting a lead compound into a drug. It is a cumbersome
process in clinical research. A quantitative personation based on computed, pharmacokinetics, physicochemical properties,
ILOGP, drug-likeness, medicinal chemistry friendliness, bioavailability radar and BOILED-Egg for all the synthesized, 6
novel compounds have been assessed using Swiss ADME. An effective drug can be produced from the physicochemical
properties discussed in this model. The physicochemical properties of all designed Schiff bases of curcumin have been
found to be optimal and so, they are perceived to have acceptable oral absorption and adequate permeability. All the
monomers obeyed the rule of five by Lipinski and the oral bioavailability is accounted worldwide. The desired set of
monomers have been enhanced by effective ADME screening and molecular simulation methods with Microtubuleassociated
protein tau (MAPT) (PDB code: 10636) receptor could represent favourable building blocks as preferable
chemotherapeutic factor in resistance to Alzheimers disease.
 
Date 2021-12-24T05:08:59Z
2021-12-24T05:08:59Z
2021-09
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscair.res.in/handle/123456789/58682
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.28(5) [September 2021]