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Michael addition mediated domino cyclization of hydrazide embedded pyrazolyl derivatives: Biological and its molecular docking examinations

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Field Value
 
Title Michael addition mediated domino cyclization of hydrazide embedded pyrazolyl derivatives: Biological and its molecular docking examinations
 
Creator Muniraj, Sarangapani
Suresh, Ganesan
 
Subject Anticancer
Chalcone
Domino
Molecular docking
Pyrazoline
Quinoline
Michael-addition
Antimicrobial
 
Description 612-617
An easing and efficiently synthesized biologically and pharmacologically active quinolinyl- tethered pyrazoline
molecules in the presence of chalcones, have been obtained from condensation of corresponding aldehydes and ketones,
through concomitant utilization of aryl hydrazide as useful starting substrates underwent Michael-addition followed by
domino cyclization. The final products have been obtained in excellent yields, and they have been well characterized using
FTIR, 1H, 13C NMR and mass spectral analyses. Moreover, all the newly synthesized molecules have been examined for the
antimicrobial and anticancer activities by MTT assay as well as molecular docking studies.
 
Date 2021-12-24T05:12:05Z
2021-12-24T05:12:05Z
2021-09
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscair.res.in/handle/123456789/58683
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.28(5) [September 2021]