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In vitro anti-oxidant and In-vitro anti-diabetic studies of silver, gold and copper nanoparticles synthesized using the flowers of Azhadirachta indica.

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Title In vitro anti-oxidant and In-vitro anti-diabetic studies of silver, gold and copper nanoparticles synthesized using the flowers of Azhadirachta indica.
 
Creator V, Gopalakrishnan
S, Muniraj
 
Subject Anti-diabetic
Anti-oxidant
Metal nanoparticles
Neem flower
A Indica
 
Description 580-586
Nanotechnology industry focuses primarily on promoting nanoscience as a “green” technology to provide a way for
less-toxic environmentally benign economic expansion and to synthesize eco- friendly and innocuous drugs to cater to the
needs of the contemporary world. An attempt has been made to prepare silver, gold and copper nanoparticles using the
aqueous flower extract of Azhadiracta indica (neem). In-vitro anti-oxidant efficacy of these metal nanoparticles (NPs) were
investigated through i) Hydrogen atom transfer (HAT) reaction based assays- (ABTS scavenging effect and Hydroxyl
radical scavenging effect) and ii) Electron transfer (ET) reaction based assays(DPPH radical scavenging activity and NO
free radical scavenging activity). CuNPs exhibits better activity compared to AgNPs and AuNPs. In vitro anti-diabetic test
was conducted for all the three NPs through three methods namely inhibition of α- glucosidase enzyme assay, inhibition of
alpha amylase enzyme assay and Non-enzymatic glycosylation of hemoglobin assay. CuNPs had a remarkable anti-diabetic
activity which was close to the standard acarbose.
 
Date 2021-12-24T05:49:34Z
2021-12-24T05:49:34Z
2021-09
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscair.res.in/handle/123456789/58689
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.28(5) [September 2021]