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Effect of myricetin on cognitive impairments in the transgenic Drosophila model of Parkinson’s Disease

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Title Effect of myricetin on cognitive impairments in the transgenic Drosophila model of Parkinson’s Disease
 
Creator Ara, Gulshan
Afzal, Mohammad
Naz, Falaq
I, Mantasha
Shahid, M.
Siddique, Yasir Hasan
 
Subject Molecular docking
Neurodegenerative disorder
α-Synuclein
 
Description 27-33
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons. Despite the availability of many drugs to ease the life of PD patients, there is no permanent cure until now. Now-a-days, there has been a considerable attention towards the use of herbal products to treat PD patients worldwide due to less side effects. In this context, here we investigated myricetin, a common plant derived flavonoid, on the cognitive impairments exhibited by the transgenic Drosophila expressing human -synuclein in the neurons. The PD flies were allowed to feed on the diet having 10, 20 and 40 μM of myricetin for 24 days and then assayed for cognitive impairments. The exposure of myricetin showed a dose dependent significant delay in the cognitive impairments. Molecular docking studies showed the positive interaction between myricetin and -synuclein. The results suggest a protective effect of myricetin against the cognitive impairments.
 
Date 2021-12-31T11:15:49Z
2021-12-31T11:15:49Z
2022-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58805
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(1) [Jan 2022]