Record Details

Prevention and amelioration of erythrocyte instability observed under deficiency of vitamin B12 alone or combined with micronutrient limitation through dietary supplementation with Chlorella and Spirulina

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Prevention and amelioration of erythrocyte instability observed under deficiency of vitamin B12 alone or combined with micronutrient limitation through dietary supplementation with Chlorella and Spirulina
 
Creator Neenu, Ravikumar
Madhubalaji, Chegukrishnamurthi
Rashmi, Venkatasubbaiah
Chauhan, Vikas Singh
Dharmesh, Shylaja M
Sarada, Ravi
 
Subject Microalgae
Micronutrients
Relative osmotic fragility
RBC stability
 
Description 7-16
Micronutrient rich microalgae, Chlorella and Spirulina, could be natural food supplements to overcome the
micronutrient deficiency, increasingly recognised as a global health issue. In two independent experiments, the Spirulina
and Chlorella were evaluated as prophylactic and ameliorative dietary supplements of vitamin B12. Erythrocyte stability
(relative osmotic fragility and haemolysis percentage), haematological parameters, micronutrient deficiency (serum levels of
iron, zinc), plasma vitamin B12 and vitamin B12 biomarker (methylmalonic acid) were analysed. The deficient groups
receiving Spirulina and Chlorella as prophylactic dietary supplements showed a 1.34 to 1.41 folds increase in serum iron
and a 2.13 to 2.19 folds increase in plasma vitamin B12, compared to B12 deficient group. Supplementation of Spirulina to
ameliorate vitamin B12 deficiency combined with micronutrient limitation showed an increase of 1.14 folds and 1.2 folds in
serum iron and zinc respectively and 1.51 folds in plasma vitamin B12 compared to the deficient group. The relative osmotic
fragility of erythrocytes in deficient experimental animals was 17 to 45% higher compared to the control. The osmotic
fragility and deformation in the morphology of erythrocytes observed under vitamin B12 deficiency, alone or in combination
with micronutrient limitation, were prevented and ameliorated on dietary supplementation with the microalgal biomass.
 
Date 2021-12-31T11:21:53Z
2021-12-31T11:21:53Z
2022-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/58807
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.60(1) [Jan 2022]