ICAR Research Data Repository for Knowledge Management
<h1><span style="font-size: small;">Synthesis, characterization and biological screening of various pharmacophoric derivatives of 4-alkylpyrimidine-5-carbonitrile</span></h1>
Online Publishing @ NISCAIR
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| Authentication Code |
dc |
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| Title Statement |
<h1><span style="font-size: small;">Synthesis, characterization and biological screening of various pharmacophoric derivatives of 4-alkylpyrimidine-5-carbonitrile</span></h1> |
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| Added Entry - Uncontrolled Name |
Thanki, Pragna H; Shree V. J. Modha College, Porbandar (Affiliated to Bhakt Kavi Narsinh Mehta University, Junagadh) Hingrajia, Dhaval V; Intas Pharmaceuticals Ltd. Modha, Jayesh J; M. D. Science College, Porbandar (Affiliated to Bhakt Kavi Narsinh Mehta University Junagadh) |
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| Uncontrolled Index Term |
Derivatives of 4-isobutyl-1,6-dihydro-1-Methyl-6-oxo pyrimidine-5-carbonitrile, antimicrobial, anticancer, CO-ADD, DTP |
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| Summary, etc. |
<p style="text-align: justify;">4-Isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile has been used as a starting material. Reaction of 4-isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile with hydrazine hydrate and amine gives 2-hydrazino and 2-(alkyl/ substituted aryl amino)-4-isobutyl-1,6-dihydro-1-methyl-6-oxopyrimidine-5-carbonitrile compounds respectively. The hydrazino compounds react with different aromatic aldehydes, substituted benzene sulphonyl chloride and s-triazine derivative to form Schiff base, sulphonamide and s-triazine derivatives respectively. Reaction of Schiff base with mercapto lactic acid and chloroacetyl chloride yield 4-thiazolidinones and 2-azetidinones respectively.</p> |
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| Publication, Distribution, Etc. |
Indian Journal of Chemistry (IJC) 2022-02-02 16:02:00 |
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| Electronic Location and Access |
application/pdf application/pdf http://op.niscair.res.in/index.php/IJC/article/view/60065 |
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| Data Source Entry |
Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 1 (2022): Indian Journal of Chemistry-(IJC) |
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| Language Note |
en |
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