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<p class="TitleMain">Synthesis of curcumin based imidazo[2,1-<em>b</em>]thiazole derivatives and their biological evaluation as antiproliferative agents</p><br />

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Title Statement <p class="TitleMain">Synthesis of curcumin based imidazo[2,1-<em>b</em>]thiazole derivatives and their biological evaluation as antiproliferative agents</p><br />
 
Added Entry - Uncontrolled Name Mallikarjun, G ; Center for Semio Chemical Laboratory, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India Government Degree College, Ibrahimpatnam (R. R. District) 501 506, Hyderabad, India
Raju, A Krishnam; Department of Chemistry, Osmania University, Hyderabad 500 007, India
Yadav, J S; Center for Semio Chemical Laboratory, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India School of Science, Indrashil University, Kadi, Mehsana 382 740, India
 
Uncontrolled Index Term Curcumin, Imidazo[2,1-b]thiazole, cytotoxicity, antiproliferative activity
 
Summary, etc. <p class="Abstract" style="text-align: justify;">Motivated by the antiproliferative potential of curcumin and imidazothiazoles, a series of curcumin based imidazo[2,1-<em>b</em>] thiazole derivatives have been prepared, characterized and evaluated for their anticancer activity against various human cancer cell lines. These synthesized compounds have been found to have appreciable to moderate activity. Consequently, compounds <strong>8a</strong> and <strong>8g</strong> display noteworthy cytotoxicity with IC<sub>50</sub> values of 7.2 μM and 4.7 μM, respectively, against A549 cell line. Furthermore, compounds <strong>8a</strong>, <strong>8b</strong> and <strong>8g</strong> exhibit substantial cytotoxicity with IC<sub>50</sub> values ranging between 9.1 μM to 9.9 μM respectively, against HeLa cell line. Interestingly, compounds <strong>8a </strong>and <strong>8g</strong> exhibit appreciable cytotoxicity with IC<sub>50</sub> values ranging between 7.5 μM to 8.7 μM respectively, against DU145 cancer cell line. Overall, four compunds (<strong>8a, 8b, 8g </strong>and<strong> 8h</strong>) demonstrate IC<sub>50</sub> values less than 10 μM against selected human cancer cell lines. They could be taken further for investigation of their mode of action and other parameters.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-02 16:02:00
 
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http://op.niscair.res.in/index.php/IJC/article/view/60046
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 1 (2022): Indian Journal of Chemistry-(IJC)
 
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