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<p>A 3D Co(II) compound: Crystal structure and protective activity on chronic nephritis</p>

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Title Statement <p>A 3D Co(II) compound: Crystal structure and protective activity on chronic nephritis</p>
 
Added Entry - Uncontrolled Name Shi, Xiu-Zhen ; Department of Nephrology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
Guo, Ai-Li ; Department of Nephrology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
Fu, Kai ; Department of Nephrology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
He, Yan ; Department of Nephrology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
Li, Qin ; Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
Luo, Qiong ; Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, Hubei, China
 
Uncontrolled Index Term Coordination polymer, Chronic nephritis, Computer simulation
 
Summary, etc. <p style="text-align: justify;">In the current study, via applying a mixed-ligand strategy, a Co(II) coordination polymer that is, {[Co<sub>4</sub>(3-dpyb)<sub>2 </sub>(odpa)<sub>2</sub>(H<sub>2</sub>O)<sub>3</sub>]·4H<sub>2</sub>O}<sub>n</sub> (<strong>1</strong>) [where 3-dpyb is <em>N</em>,<em>N</em>′-bis(3-pyridinecarboxamide)-1,4-butane, and H<sub>4</sub>odpa represents 4,4′-oxydiphthalic acid] is produced through reaction between two organic ligands and Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O in the water and DMF mixed solvents. For the treatment of chronic nephritis, real time RT-PCR is employed for measuring the AMPK signaling pathway activation, and ELISA detection kit is applied to evaluate inflammatory cytokines content released into plasma. Computer simulation has revealed that the activity of the proposed candidate is only from the carboxyl function groups, however, nitrogen atoms from both amide and pyridine groups only showed limited activity to the protein.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-02 16:02:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/60051
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 1 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en