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<p>Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives</p>

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Title Statement <p>Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives</p>
 
Added Entry - Uncontrolled Name Ravikumar, D ; Department of Chemistry, Bapatla Engineering College, Bapatla 522 101, India
Subramanyam, Ch ; Department of Chemistry, Bapatla Engineering College, Bapatla 522 101, India
Venkataramaiah, Ch ; Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India
Rajendra, W ; Division of Molecular Biology, Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India
Rao, K Prasada; Department of Chemistry, Bapatla Engineering College, Bapatla 522 101, India
 
Uncontrolled Index Term Phosphoramidates, 4-chlorobenzene sulfonyl chloride, molecular docking studies, anti-diabetic activity
 
Summary, etc. <p style="text-align: justify;">In the present work, a series of new phosphoramidate derivatives have been conveniently synthesized by using 4-chlorobenzene-sulfonyl chloride as preliminary material <em>via</em> substituted sulfonamides as intermediates with high yields in a short period by conventional and microwave irradiation techniques. All the synthesized compound have been characterized by spectral and elemental analyses. An <em>in silico</em> molecular docking study has been performed to find potent anti-diabetic drugs. <em>In vitro</em> anti-diabetic activity of the title compounds have also been screened by standard α-amylase inhibition assay. Some of the tested compounds have been proven to possess promising activity when compared with reference drug.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-02 16:02:00
 
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http://op.niscair.res.in/index.php/IJC/article/view/60061
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 1 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en