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<p>Synthesis of photoactivable Pt(IV) prodrug loaded on NaYF<sub>4</sub> based upconversion nanoparticles functionalized with 2-deoxy-D-glucose and its evaluation for targeted cancer therapy</p>

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Title Statement <p>Synthesis of photoactivable Pt(IV) prodrug loaded on NaYF<sub>4</sub> based upconversion nanoparticles functionalized with 2-deoxy-D-glucose and its evaluation for targeted cancer therapy</p>
 
Added Entry - Uncontrolled Name Sharma, K Shitaljit; Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India Department of Chemistry, Mizoram University, Aizawl 796 009, India
Tiewsoh, Lodestarborn ; North-Eastern Hill University, Shillong 793 022, India
Dubey, Akhil K; Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Phadnis, Prasad P; Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India Homi Bhabha National Institute, Anushaktinagar, Mumbai 400 094, India
Sudarsan, V ; Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India Homi Bhabha National Institute, Anushaktinagar, Mumbai 400 094, India
Vatsa, Rajesh K; Homi Bhabha National Institute, Anushaktinagar, Mumbai 400 094, India Department of Atomic Energy, Mumbai 400 001, India
 
Uncontrolled Index Term Photoactivable, Pt(IV) prodrug, Upconversion nanoparticles, 2-deoxy-D-glucose, Internalization, Clonogenic assay
 
Summary, etc. Nano-formulation based on Tm, Yb doped NaYF<sub>4</sub> upconversion nanoparticles (UCNPs) functionalized with 2-deoxy-D-glucose have been synthesized to load the photoactivable Pt(IV) prodrug, cis-[PtI<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(OCOCH<sub>2</sub>CH<sub>2</sub>COOH)<sub>2</sub>]. The Pt(IV) prodrug has been synthesized by oxidation of cis-[PtI<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>] to [PtI<sub>2</sub>(OH)<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>] and its further treatment with succinic anhydride. It is loaded through ester bond formation between the carboxyl groups of Pt(IV) prodrug with hydroxyl groups of 2-deoxy-D-glucose (2-DG) coated on UCNPs. The cytotoxicity of formulation after exposing to 385 nm UV light and in absence of light is evaluated against MCF-7 cell lines by MTT assay. The results have revealed enhanced cytotoxicity of UV exposed nano-formulation. Additionally, the clonogenic assay has exhibited the decrease in plating efficiency as inferred from decreased surviving fraction around 20% only for UV activated formulation as compared to formulation in dark, as well as merely Pt(IV) prodrug. These results are indicative that more internalization of the formulation inside the cancer cells was achieved due to the presence of 2-DG rendering more efficiency to kill cancer cells.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-02 16:02:00
 
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http://op.niscair.res.in/index.php/IJC/article/view/60047
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 1 (2022): Indian Journal of Chemistry-(IJC)
 
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