Record Details

Synthesis, characterization, molecular docking and antibacterial activities of Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxopropanamideZinc (II) complex

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Synthesis, characterization, molecular docking and antibacterial activities of Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxopropanamideZinc (II) complex
 
Added Entry - Uncontrolled Name Kothari, Richa
Agrawal, Anurag
Rai, Sanchita
 
Uncontrolled Index Term Antibacterial activity; Hydrazones; Molecular docking; XRD; Zinc (II) complex
 
Summary, etc. The title Zn (II) complex was synthesized by reacting the compound Bis-[(E)-3{2-(1-4-chlorophenyl) ethylidiene}hydrazinyl]-N-(4-methylphenyl)-3-oxo propanamide with Zn (II) chloride dihydrate in alkaline dimethylsulphoxide and ethanol solution under reflexing condition for 8 h. The resultant compound was filtered and recrystallized from ethanol. The hydrazone Schiff base ligand and its Zn (II) complex were characterized by using UV-Vis spectroscopy and XRD, TEM and SEM analysis. The antibacterial activities of ligand and its Zn complex were examined using disc diffusion method. The spectra results showed that the hydrazone ligand undergoes keto-enoltautomerism forming a bidentated ligand (N,N) towards Zn+2 (II) ion. It is very interesting that on sides of the two hydrazone ligands which coordinate to the Zn+2 ions, an additional two thiosemicarbazine moiety were also coordinated with Zn+2 ions in the crystalline powder, resulting in a hexa coordinated octahedral Zn (II) complex. Both hydrazone Schiff base ligand and its Zn (II) complex were found to exhibit good antibacterial activity even when the concentrations were high. Molecular docking analysis also deciphered that Zinc complex and carbohydrazone ligand both were found to be fitted into the active sites of molecular targets and Zn complex showed better binding affinities towards macromolecules compared to ligand.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2022-02-03 00:00:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/41323
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 59 (1) [January 2022]
 
Language Note en