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Synthesis, characterization and biological screening of various pharmacophoric derivatives of 4-alkylpyrimidine-5-carbonitrile
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
Synthesis, characterization and biological screening of various pharmacophoric derivatives of 4-alkylpyrimidine-5-carbonitrile
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| Creator |
Thanki, Pragna H
Hingrajia, Dhaval V Modha, Jayesh J |
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| Subject |
Derivatives of 4-isobutyl-1
6-dihydro-1-Methyl-6-oxo pyrimidine-5-carbonitrile antimicrobial anticancer CO-ADD DTP |
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| Description |
81-87
4-Isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile has been used as a starting material. Reaction of 4-isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile with hydrazine hydrate and amine gives 2-hydrazino and 2-(alkyl/ substituted aryl amino)-4-isobutyl-1,6-dihydro-1-methyl-6-oxopyrimidine-5- carbonitrile compounds respectively. The hydrazino compounds react with different aromatic aldehydes, substituted benzene sulphonyl chloride and s-triazine derivative to form Schiff base, sulphonamide and s-triazine derivatives respectively. Reaction of Schiff base with mercapto lactic acid and chloroacetyl chloride yield 4-thiazolidinones and 2-azetidinones respectively. |
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| Date |
2022-02-01T10:40:57Z
2022-02-01T10:40:57Z 2022-01 |
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| Type |
Article
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| Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59036 |
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| Language |
en
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| Publisher |
NIScPR-CSIR, India
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| Source |
IJC Vol.61(01) [January 2022]
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