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Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives

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Title Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives
 
Creator Ravikumar, D
Subramanyam, Ch
Venkataramaiah, Ch
Rajendra, W
Rao, K Prasada
 
Subject Phosphoramidates
4-chlorobenzene sulfonyl chloride
molecular docking studies
anti-diabetic activity
 
Description 60-68
In the present work, a series of new phosphoramidate derivatives have been conveniently synthesized by using 4-
chlorobenzene-sulfonyl chloride as preliminary material via substituted sulfonamides as intermediates with high yields in a
short period by conventional and microwave irradiation techniques. All the synthesized compound have been characterized
by spectral and elemental analyses. An in silico molecular docking study has been performed to find potent anti-diabetic
drugs. In vitro anti-diabetic activity of the title compounds have also been screened by standard α-amylase inhibition assay.
Some of the tested compounds have been proven to possess promising activity when compared with reference drug.
 
Date 2022-02-01T11:37:25Z
2022-02-01T11:37:25Z
2022-01
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59038
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(01) [January 2022]