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Synthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agents

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Title Synthesis of curcumin based imidazo[2,1-b]thiazole derivatives and their biological evaluation as antiproliferative agents
 
Creator Mallikarjun, G
Raju, A Krishnam
Yadav, J S
 
Subject Curcumin
Imidazo[2,1-b]thiazole
cytotoxicity
antiproliferative activity
 
Description 13-20
Motivated by the antiproliferative potential of curcumin and imidazothiazoles, a series of curcumin based imidazo[2,1-b]
thiazole derivatives have been prepared, characterized and evaluated for their anticancer activity against various human
cancer cell lines. These synthesized compounds have been found to have appreciable to moderate activity. Consequently,
compounds 8a and 8g display noteworthy cytotoxicity with IC50 values of 7.2 μM and 4.7 μM, respectively, against A549
cell line. Furthermore, compounds 8a, 8b and 8g exhibit substantial cytotoxicity with IC50 values ranging between 9.1 μM to
9.9 μM respectively, against HeLa cell line. Interestingly, compounds 8a and 8g exhibit appreciable cytotoxicity with IC50
values ranging between 7.5 μM to 8.7 μM respectively, against DU145 cancer cell line. Overall, four compunds (8a, 8b, 8g
and 8h) demonstrate IC50 values less than 10 μM against selected human cancer cell lines. They could be taken further for
investigation of their mode of action and other parameters.
 
Date 2022-02-01T11:51:39Z
2022-02-01T11:51:39Z
2022-01
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59044
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(01) [January 2022]