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A single-center non-blinded randomized clinical trial to assess the safety and effectiveness of PhR160 spray the treatment of COVID-19 pneumonia

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Title Statement A single-center non-blinded randomized clinical trial to assess the safety and effectiveness of PhR160 spray the treatment of COVID-19 pneumonia
 
Added Entry - Uncontrolled Name Sheikh Roshandel, Hamidreza
Mirkazemi, Roksana
Ahmadabadi, Hamidreza
Memarzadeh, Mohammadreza
Zahedifard, Navid
Saffari, Mostafa
Jazani, Majid
Rahmani, Monire
Hosseini, Morteza
Raei, mehdi
Sharifi Olounabadi, Ahmadreza
Ghadimi, Fateme
Ameli, Pantea
Valinejad, Mehdi
Mohtashami, Reza ; Faculty Member, Internist (MD), Medicine, Quran and Hadith Research Center, Baqiatallah University Medical Sciences
There was no source of funding for this study
 
Uncontrolled Index Term COVID-19, Hospitalized patients, Iranian Traditional Medicine, Pinen-Hydronoplacton-Ribonucleic acid (PHR160)
 
Summary, etc. <p>COVID-19 is an emerging pandemic that caused a very widespread infection with more than 1000000 cases in Iran within a year. The main cause of mortality among patients with COVID-19 is pulmonary failure. In Iranian Traditional Medicine, essences have been used for curing pulmonary diseases. Pinen-Hydeonoplacton-Ribonucleic acid (PHR) is an inhaler spray made of seven different plants, which all are used by humans, have desirable pharmacological features for treating pulmonary symptoms of COVID-19 patients. This study was conducted to assess the safety and effectiveness of PHR160 spray in improving pulmonary symptoms of COVID-19 patients.</p> <p>This was a single-center, non-blinded randomized clinical trial with two parallel groups in two different wards of Baqiyatallah hospital, Tehran, Iran.</p> <p>Participants were 51 male patients, diagnosed with COVID-19 pneumonia, divided into 2 groups of 32 in the intervention group and 31 in the control group.</p> <p>The intervention group received 5 days of PHR160 spray, 10 puffs each day, 300 micrograms in each puff in addition to the routine treatment.</p> <p>Oxygen saturation was measured by a pulse oximeter, every 6 hours and recorded daily</p> <p>This study showed that the intervention increased significantly the arterial oxygen saturation percentage in COVID-19 patients. In addition, it decreases hospitalization duration, dyspnea score and cough score significantly in the patients. The statistical modeling test, with adjusting the age and respiratory rate for baseline and 4 days of the intervention, shows that the oxygen saturation percentage mean was significantly more in the intervention group by 5.14 units (p&lt;0.001).</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2022-02-09 16:35:14
 
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http://op.niscair.res.in/index.php/IJTK/article/view/47342
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 21, ##issue.no## 1 (2022): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/47342/465553560
http://op.niscair.res.in/index.php/IJTK/article/download/47342/465553561