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Anticonvulsant and antioxidant effect of hydroalcoholic extract of Valeriana wallichii rhizomes in acute and chronic models of epilepsy in albino rats

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Title Anticonvulsant and antioxidant effect of hydroalcoholic extract of Valeriana wallichii rhizomes in acute and chronic models of epilepsy in albino rats
 
Creator Chowdhury, Bimalendu
Acharya, Biswajeet
Sahu, Debasis
 
Subject Catalase
Glutathione
Malondialdehyde
Nitric oxide
Oxidative stress
Seizure
Superoxide dismutase
Valeriana wallichii.
 
Description 585-591
Oxidative stress plays an important role in the aetiology of seizure-induced neuronal death. The present study was aimed to evaluate the anticonvulsant and antioxidant activity of hydroalcoholic extract of Valeriana wallichii (HAEVW) rhizomes in albino rats. Flavonoids possess a potent anticonvulsant effect through modulation of GABA/BDZ receptor and neuroprotective effect by regulating oxidative stress in PTZ-induced convulsion. Total phenolics and flavonoids content of HAEVW rhizomes were measured and the anticonvulsant activity was evaluated using PTZ and MES induced convulsion models. The in-vivo antioxidant activity was evaluated using the PTZ-kindled model by estimating brain malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and nitric oxide (NO). It was observed that the flavonoids content of the extract was 80% of the total phenolics content and HAEVW (200 and 400 mg/kg) showed a significant (P
 
Date 2022-02-15T10:06:28Z
2022-02-15T10:06:28Z
2021-12
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59172
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 36/84, A61K 125/00, A61P 25/00, A61P 25/08
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(4) [December 2021]