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Orchid Dendrobium alpestre Royle enhances survival in lethal sepsis induced in mice

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Field Value
 
Title Orchid Dendrobium alpestre Royle enhances survival in lethal sepsis induced in mice
 
Creator Tatipamula, Vinay Bharadwaj
Tatipamula, Sasikanth
 
Subject Anti-bacterial agent
CLP-induced sepsis
Hemodynamics parameters
Myeloperoxidase activity
 
Description 564-569
Despite advances in medical care and therapy, sepsis is still one of the major causes of death in intensive care units, and
no decisive medical treatment is available against sepsis. The present study investigated the antibacterial activity, acute
toxicity studies, hemodynamic parameters, myeloperoxidase (MPO) activity of hydroalcoholic extract of Dendrobium
alpestre (Da), and its effects on cecal ligation and puncture (CLP) induced sepsis in mice. At equivalent concentration,
Da showed antibacterial activities as potent as streptomycin against Staphylococcus aureus and Escherichia coli. Acute
toxicity studies on mice found out that Da was non-toxic up to 2000 mg/Kg body weight, and the low and high dose was
fixed as 100 and 200 mg/Kg body weight, respectively. At both doses, Da improved hemodynamic parameters such as mean
arterial pressure and decreased optical density of blood, while it decreased serum MPO activity. Moreover, at a high dose,
Da reduced the survival rate to 92.50±3.50% in mice that might be through pro-inflammatory effects. The results indicate
that D. alpestre can be a favourable natural source for the treatment of CLP-induced sepsis in mice.
 
Date 2022-02-15T10:15:20Z
2022-02-15T10:15:20Z
2021-12
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59177
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 36/898, A61P 31/04
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(4) [December 2021]