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In vitro antidiabetic and anti-inflammatory activities of the bark of Ehretia acuminata R.Br.

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Title In vitro antidiabetic and anti-inflammatory activities of the bark of Ehretia acuminata R.Br.
 
Creator Kaur, Amanpreet
Shukla, Abha
Shukla, Rishi Kumar
 
Subject Antidiabetic
Anti-inflammatory
Ehretia acuminata R.Br.
α-Amylase
α-Glucosidase.
 
Description 538-543
Ehretia acuminata is native to Southeast Asia, America, and Africa. It is commonly used as fodder and in quite a variety
of medicinal applications. E. acuminata is widely used in India, but there are few reports in the literature of studies on its
biological properties. In this study, the antidiabetic and anti-inflammatory activities of plant E. acuminata was evaluated.
The antidiabetic activity of the different extracts was measured by α-amylase and α-glycosidase inhibition method. The antiinflammatory
activity was evaluated by the egg albumin of hen. Petroleum ether, chloroform, ethyl acetate, ethanol and
water extracts of bark of E. acuminata was evaluated for in-vitro anti-inflammatory and antidiabetic activity. Ethyl acetate
and ethanol extract showed significant anti-inflammatory effects (IC50 170 and 172 μg/mL respectively). Chloroform is the
only extract that showed significant inhibition against the antidiabetic effect (IC50 42-45 μg/mL). The findings suggest that
the bark of E. acuminata contains potential antidiabetic and anti-inflammatory compounds, which could be tested as drug
candidates against diabetic and inflammation-related pathological processes in medicinal chemistry studies.
 
Date 2022-02-15T10:24:38Z
2022-02-15T10:24:38Z
2021-12
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59181
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 129/00, A61P 3/00, A61P 3/10, A61P 29/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(4) [December 2021]