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Terpenoids from Centella asiatica, a novel inhibitor against RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)

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Title Terpenoids from Centella asiatica, a novel inhibitor against RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)
 
Creator Consul, Chitrakshi
Beg, Md Amjad
Thakur, Sonu Chand
 
Subject Centella asiatica
Covid-19
Molecular docking
RdRp
Terpenoids
 
Description 527-537
Covid-19, the first case of which was reported in Wuhan (China) in December 2019 was found to be a strain of coronaviruses like SARS and MERS reported earlier. These viruses are positive strain RNA viruses composed of both structural as well as non-structural proteins. The enzyme RdRp (RNA dependent RNA polymerase) stands responsible for catalyzing the replication of this virus within the host cell. A disruption in the core catalytic subunit composed of nsp12, nsp7, and nsp8 may inhibit the replication of the same. Different drugs targeting different sites on the virus have been developed. In this context, some of the natural products of the plant Centella asiatica was lead for further drug development against the target proteins of RdRp protein (PDB ID: 6NUR) through molecular docking. These compounds are 2,3-dihydroxyurs-12-en-28-oic acid, corosolic acid and pomolic acid which are triterpenoids and have highest binding affinity against RdRp protein thereby arresting the viral replication. Several previous studies showed triterpenoids as pertinent mediators implicated in the in vitro immune response.
 
Date 2022-02-15T10:27:31Z
2022-02-15T10:27:31Z
2021-12
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/59182
 
Language en
 
Relation Int. cl. (2015.01)- A61K 36/00, A61K 36/23, A61P 31/12, A61P 31/14
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.12(4) [December 2021]