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Synthesis and antimicrobial activity of novel 1H-benzo[d]imidazole-aryl sulfonamide/amide derivatives

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Title Synthesis and antimicrobial activity of novel 1H-benzo[d]imidazole-aryl sulfonamide/amide derivatives
 
Creator Jadhav, Rahul I
Kedar, Nathrao A
Chavan, Kamlesh H
 
Subject 1H-Benzo[d]imidazole
sulfonamide
amide
antifungal
antibacterial
MIC
 
Description 184-191
A series of novel N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl)-aryl sulfonamide and amide derivatives have been
synthesized. The structure of all newly synthesized 1H-benzo[d]imidazole derivatives have been confirmed using spectral
analysis and evaluated for antibacterial, antifungal potential. Biological evaluations study reveals that the compounds 2, 3, 5,
7 and 15 are found to have moderate to good antimicrobial activity (MIC range of 10–20 mg/mL) against the bacterial
strains Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 8739 in comparison to standard Ampicillin as well
as fungal strains Candida albicans ATCC 10231 and Aspergillus niger ATCC 6275 in comparison to Fluconazole. These
results suggest that this could be the start of an extensive medicinal chemistry program to identify the 1Hbenzo[
d]imidazole-aryl sulfonamide based potent antimicrobial agents.
 
Date 2022-02-16T05:55:40Z
2022-02-16T05:55:40Z
2022-02
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59190
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(02) [February 2022]