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Synthesis, in vitro biological evaluation and molecular docking study of coumarin- 1,4-dihydropyridine derivatives as potent anti-inflammatory agents

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Title Synthesis, in vitro biological evaluation and molecular docking study of coumarin- 1,4-dihydropyridine derivatives as potent anti-inflammatory agents
 
Creator Madar, Jyoti M
Shastri, Lokesh A
Shastri, Samundeeswari L
Holiyachi, Megharaja
Naik, Nirmala S
Gudimani, Parashuram
Pawar, Varsha
Shettar, Arun K
Joshi, Shrinivas D
Sungar, Vinay A
 
Subject Coumarin-1,4-dihydropyridine
antimicrobial activity
anti-inflammatory activity
molecular docking study
green protocol
 
Description 159-173
The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential
multi-component reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been
successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity
results of the title compounds show potent activity against both Gram positive and Gram negative bacterial and fungal
stains. Additionally, anti-inflammatory activity of all the compounds have been found to be quite promising in comparison
with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with
S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the
in vitro antibacterial and anti-inflammatory findings.
 
Date 2022-02-16T06:41:37Z
2022-02-16T06:41:37Z
2022-02
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59192
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(02) [February 2022]