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<p>Synthesis and antimicrobial activity of novel 1<em>H</em>-benzo[<em>d</em>]imidazole-aryl sulfonamide/amide derivatives</p>

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Title Statement <p>Synthesis and antimicrobial activity of novel 1<em>H</em>-benzo[<em>d</em>]imidazole-aryl sulfonamide/amide derivatives</p>
 
Added Entry - Uncontrolled Name Jadhav, Rahul I ; Research Centre and Post Graduate Department of Chemistry, Netaji Subash Chandra Bose Arts Commerce and Science College, Vazirabad, Nanded 431 601, India
Kedar, Nathrao A ; Research Centre and Post Graduate Department of Chemistry, Netaji Subash Chandra Bose Arts Commerce and Science College, Vazirabad, Nanded 431 601, India Department of Chemistry, Dayanand Science College, Latur 413 512, India
Chavan, Kamlesh H ; Research Centre and Post Graduate Department of Chemistry, Netaji Subash Chandra Bose Arts Commerce and Science College, Vazirabad, Nanded 431 601, India
 
Uncontrolled Index Term 1H-Benzo[d]imidazole, sulfonamide, amide, antifungal, antibacterial, MIC
 
Summary, etc. <p style="text-align: justify;">A series of novel <em>N</em>-(6-(propylthio)-1<em>H</em>-benzo[<em>d</em>]imidazol-2-yl)-aryl sulfonamide and amide derivatives have been synthesized. The structure of all newly synthesized 1<em>H</em>-benzo[<em>d</em>]imidazole derivatives have been confirmed using spectral analysis and evaluated for antibacterial, antifungal potential. Biological evaluations study reveals that the compounds <strong>2, 3, 5, 7</strong> and <strong>15</strong> are found to have moderate to good antimicrobial activity (MIC range of 10–20 mg/mL) against the bacterial strains <em>Staphylococcus </em><em>aureus <strong>ATCC 6538 </strong></em>and <em>Escherichia</em><em> coli <strong>ATCC 8739 </strong></em>in comparison to standard Ampicillin as well as fungal strains <em>Candida </em><em>albicans <strong>ATCC 10231 </strong></em>and <em>Aspergillus </em><em>niger<strong> ATCC 6275</strong></em> in comparison to Fluconazole. These results suggest that this could be the start of an extensive medicinal chemistry program to identify the 1<em>H</em>-benzo[<em>d</em>]imidazole-aryl sulfonamide based potent antimicrobial agents.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-21 00:00:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJC/article/view/60716
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 2 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en