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<p class="TitleMain">Synthesis, <em>in vitro</em> biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents</p>

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Title Statement <p class="TitleMain">Synthesis, <em>in vitro</em> biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents</p>
 
Added Entry - Uncontrolled Name Madar, Jyoti M ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Shastri, Lokesh A ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Shastri, Samundeeswari L ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Holiyachi, Megharaja ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Naik, Nirmala S ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Gudimani, Parashuram ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Pawar, Varsha ; Department of Chemistry, Karnatak University, Dharwad 580 003, India
Shettar, Arun K ; PG Department of Studies and Research in Biotechnology and Bioinformatics Akkamahadevi Women’s University, Vijayapure 586 108, India
Joshi, Shrinivas D ; Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T.’s College of Pharmacy, Sangolli Rayanna Nagar, Dharwad 580 002, India
Sungar, Vinay A ; Department of Chemistry, G.S.S. College, Belagavi 590 006, India
 
Uncontrolled Index Term Coumarin-1,4-dihydropyridine, antimicrobial activity, anti-inflammatory activity, molecular docking study, green protocol
 
Summary, etc. <p class="Abstract" style="text-align: justify;">The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds <strong>6a-o</strong> <em>via</em> sequential multi-component reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds show potent activity against both Gram positive and Gram negative bacterial and fungal stains. Additionally, anti-inflammatory activity of all the compounds have been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the <em>in silico</em> docking study has been performed for all the compounds with <em>S. aureus</em> DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the <em>in vitro</em> antibacterial and anti-inflammatory findings.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-02-21 00:00:00
 
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http://op.niscair.res.in/index.php/IJC/article/view/60711
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 2 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en