Record Details

In vitro anticancer activity of ethanolic extract of Stoechospermum marginatum against HT-29 human colon adenocarcinoma cells

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement In vitro anticancer activity of ethanolic extract of Stoechospermum marginatum against HT-29 human colon adenocarcinoma cells
 
Added Entry - Uncontrolled Name Kalaiselvi, Lakshmanan ; Madras Veterinary College
Padmanabhan, Sriram ; Professor and Head (Retd) Department of Veterinary Pharmacology and Toxicology Madras Veterinary College Chennai-7
SP, Preetha ; Assistant Professor Department of Veterinary Pharmacology and Toxicology Madras Veterinary College Chennai-600 007
RP, Aravindh Babu ; Scientist & Assistant professor Translational Research Platform for Veterinary Biologicals, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India
M, Parthiban ; Professor and Head Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India
TA, Kannan ; Department of Veterinary Anatomy, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu, India
Tamil Nadu Veterinary and Animal Sciences University
 
Uncontrolled Index Term Antiproliferative; Apoptosis; Brown algae; Chemotherapeutic; Cytotoxicity; Seaweed extract
 
Summary, etc. Colorectal cancer is a one of the leading causes of death globally and its clinical management of cancer involves chemotherapy. Increase in the development of resistance to the drugs used in the cancer treatment and serious side effects associated with chemotherapeutic drugs are the major limitations in cancer therapy. Hence, there exists a huge need to develop safer natural therapeutic products for cancer therapy. In this study, ethanolic extract of Stoechospermum marginatum was evaluated for its anticancer activity. The cytotoxicity of S. marginatum extract was evaluated on HT-29 cells by MTT assay. Trypan blue cell viability was also carried out to evaluate cytotoxicity and antiproliferative effect. The apoptosis-inducing potential of the extract was analyzed by acridine orange and ethidium bromide dual staining method, mitochondrial membrane potential assay and FITC Annexin V-Propidium iodide staining method. The ethanolic extract of S. marginatum showed significant dose-dependent cytotoxicity in HT-29 cells Treatment with S. marginatum extract increased number of apoptotic cells in HT-29 cells and caused damage to mitochondrial membrane potential. The findings of the present study confirmed in vitro anticancer activity of ethanolic extract S. marginatum
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-03-03 16:32:24
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJEB/article/view/39245
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 60, ##issue.no## 03 (2022): IJEB [March 2022]
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJEB/article/download/39245/465522049