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<em>In vitro</em> antidiabetic and anti-inflammatory activities of the bark of <em>Ehretia acuminata</em> R.Br.

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Title Statement <em>In vitro</em> antidiabetic and anti-inflammatory activities of the bark of <em>Ehretia acuminata</em> R.Br.
 
Added Entry - Uncontrolled Name Kaur, Amanpreet ; Department of Chemistry, Kanya Gurukula Campus, Gurukula Kangri Vishwavidyalaya, Haridwar 249404, Uttarakhand, India
Shukla, Abha ; Department of Chemistry, Kanya Gurukula Campus, Gurukula Kangri Vishwavidyalaya, Haridwar 249404, Uttarakhand, India
Shukla, Rishi Kumar; Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar 249404, Uttarakhand, India
none
 
Uncontrolled Index Term Chemistry, Phytochemistry
Antidiabetic; Anti-inflammatory; Ehretia acuminata R.Br.; α-Amylase; α-Glucosidase.
 
Summary, etc. <p style="text-align: justify;"><em>Ehretia </em><em>acuminata</em> is native to Southeast Asia, America, and Africa. It is commonly used as fodder and in quite a variety of medicinal applications. <em>E. </em><em>acuminata</em> is widely used in India, but there are few reports in the literature of studies on its biological properties. In this study, the antidiabetic and anti-inflammatory activities of plant <em>E. acuminata </em>was evaluated. The antidiabetic activity of the different extracts was measured by α-amylase and α-glycosidase inhibition method. The anti-inflammatory activity was evaluated by the egg albumin of hen. Petroleum ether, chloroform, ethyl acetate, ethanol and water extracts of bark of <em>E. acuminata </em>was evaluated for <em>in-vitro</em> anti-inflammatory and antidiabetic activity. Ethyl acetate and ethanol extract showed significant anti-inflammatory effects (IC<sub>50 </sub>170 and 172 µg/mL respectively). Chloroform is the only extract that showed significant inhibition against the antidiabetic effect (IC<sub>50 </sub>42-45 µg/mL). The findings suggest that the bark of <em>E. acuminata </em>contains potential antidiabetic and anti-inflammatory compounds, which could be tested as drug candidates against diabetic and inflammation-related pathological processes in medicinal chemistry studies.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-03-15 11:16:10
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/29108
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 4 (2021): DECEMBER 2021
 
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