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<p style="text-align: justify;">Orchid <em>Dendrobium alpestre</em> Royle enhances survival in lethal sepsis induced in mice</p>

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Title Statement <p style="text-align: justify;">Orchid <em>Dendrobium alpestre</em> Royle enhances survival in lethal sepsis induced in mice</p>
 
Added Entry - Uncontrolled Name Tatipamula, Vinay Bharadwaj; Institute of Research and Development, Faculty of Pharmacy, Duy Tan University, Da Nang 550000, Vietnam
Tatipamula, Sasikanth ; Oil and Natural Gas Corporation, Dronagiri Bhawan Uran, Mumbai 400702, Maharashtra, India
 
Uncontrolled Index Term natural products chemistry; pharmacology
Anti-bacterial agent; CLP-induced sepsis; Hemodynamics parameters; Myeloperoxidase activity.
 
Summary, etc. <p style="text-align: justify;">Despite advances in medical care and therapy, sepsis is still one of the major causes of death in intensive care units, and no decisive medical treatment is available against sepsis. The present study investigated the antibacterial activity, acute toxicity studies, hemodynamic parameters, myeloperoxidase (MPO) activity of hydroalcoholic extract of <em>Dendrobium alpestre </em>(Da), and its effects on cecal ligation and puncture (CLP) induced sepsis in mice. At equivalent concentration, Da showed antibacterial activities as potent as streptomycin against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>. Acute toxicity studies on mice found out that Da was non-toxic up to 2000 mg/Kg body weight, and the low and high dose was fixed as 100 and 200 mg/Kg body weight, respectively. At both doses, Da improved hemodynamic parameters such as mean arterial pressure and decreased optical density of blood, while it decreased serum MPO activity. Moreover, at a high dose, Da reduced the survival rate to 92.50±3.50% in mice that might be through pro-inflammatory effects. The results indicate that <em>D. alpestre</em> can be a favourable natural source for the treatment of CLP-induced sepsis in mice.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-03-15 11:16:10
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/38920
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 4 (2021): DECEMBER 2021
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/38920/465521063
http://op.niscair.res.in/index.php/IJNPR/article/download/38920/465521064
 
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