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<p style="text-align: justify;">Anticonvulsant and antioxidant effect of hydroalcoholic extract of <em>Valeriana wallichii</em> rhizomes in acute and chronic models of epilepsy in albino rats</p>

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Title Statement <p style="text-align: justify;">Anticonvulsant and antioxidant effect of hydroalcoholic extract of <em>Valeriana wallichii</em> rhizomes in acute and chronic models of epilepsy in albino rats</p>
 
Added Entry - Uncontrolled Name Chowdhury, Bimalendu ; Department of pharmacology, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur 760010, Odisha, India
Acharya, Biswajeet ; Department of pharmacology, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur 760010, Odisha, India
Sahu, Debasis ; Department of pharmacology, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur 760010, Odisha, India
 
Uncontrolled Index Term Pharmacology
Catalase; Glutathione; Malondialdehyde; Nitric oxide; Oxidative stress; Seizure; Superoxide dismutase; Valeriana wallichii.
 
Summary, etc. <p style="text-align: justify;">Oxidative stress plays an important role in the aetiology of seizure-induced neuronal death. The present study was aimed to evaluate the anticonvulsant and antioxidant activity of hydroalcoholic extract of <em>Valeriana wallichii </em>(HAEVW) rhizomes in albino rats. Flavonoids possess a potent anticonvulsant effect through modulation of GABA/BDZ receptor and neuroprotective effect by regulating oxidative stress in PTZ-induced convulsion. Total phenolics and flavonoids content of HAEVW rhizomes were measured and the anticonvulsant activity was evaluated using PTZ and MES induced convulsion models. The <em>in-vivo</em> antioxidant activity was evaluated using the PTZ-kindled model by estimating brain malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and nitric oxide (NO). It was observed that the flavonoids content of the extract was 80% of the total phenolics content and HAEVW (200 and 400 mg/kg) showed a significant (<em>P</em> &lt;0.01) delay in onset, decrease in duration of tonic convulsion and hind limb tonic extension (HLTE) in PTZ and MES induced convulsion respectively. In the PTZ-kindling model, HAEVW rhizomes (400 mg/kg) restored the MDA and all antioxidant parameters to normal except NO. It was concluded that flavonoids of rhizomes of <em>V. wallichii</em> may be responsible for the anticonvulsant and antioxidant activity of the extract.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-03-15 11:16:10
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/45216
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 4 (2021): DECEMBER 2021
 
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http://op.niscair.res.in/index.php/IJNPR/article/download/45216/465549115
http://op.niscair.res.in/index.php/IJNPR/article/download/45216/465549116
 
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