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<p style="text-align: justify;">Terpenoids from <em>Centella asiatica</em>, a novel inhibitor against RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)</p>

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Title Statement <p style="text-align: justify;">Terpenoids from <em>Centella asiatica</em>, a novel inhibitor against RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)</p>
 
Added Entry - Uncontrolled Name Consul, Chitrakshi ; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
Beg, Md Amjad; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
Thakur, Sonu Chand; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
 
Uncontrolled Index Term Diseases; utilization of plants.
Centella asiatica; Covid-19; Molecular docking; RdRp; Terpenoids.
 
Summary, etc. <p style="text-align: justify;">Covid-19, the first case of which was reported in Wuhan (China) in December 2019 was found to be a strain of coronaviruses like SARS and MERS reported earlier. These viruses are positive strain RNA viruses composed of both structural as well as non-structural proteins. The enzyme RdRp (RNA dependent RNA polymerase) stands responsible for catalyzing the replication of this virus within the host cell. A disruption in the core catalytic subunit composed of nsp12, nsp7, and nsp8 may inhibit the replication of the same. Different drugs targeting different sites on the virus have been developed. In this context, some of the natural products of the plant <em>Centella asiatica</em> was lead for further drug development against the target proteins of RdRp protein (PDB ID: 6NUR) through molecular docking. These compounds are 2,3-dihydroxyurs-12-en-28-oic acid, corosolic acid and pomolic acid which are triterpenoids and have highest binding affinity against RdRp protein thereby arresting the viral replication. Several previous studies showed triterpenoids as pertinent mediators implicated in the<em> in vitro</em> immune response.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-03-15 11:16:10
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/43764
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 12, ##issue.no## 4 (2021): DECEMBER 2021
 
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