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A green method for the synthesis of isoxazolyl aryl thieno[2,3-d]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity
NOPR - NISCAIR Online Periodicals Repository
View Archive Info| Field | Value | |
| Title |
A green method for the synthesis of isoxazolyl aryl thieno[2,3-d]pyrimidinones using reusable polyethylene glycol as simple solvent catalyst and evaluation of anti-microbial activity
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| Creator |
Saini, Ramakrishna
Malladi, Srinivas Reddy Dharavath, Nagaraju |
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| Subject |
Green synthesis
polyethylene glycol (PEG) isoxazolylarylthieno[2,3-d]pyrimidinones antimicrobial activity |
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| Description |
336-347
Novel series of isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been synthesized from (E)-2-amino-5-(3-methyl-4- nitroisoxazol-5-yl)-N-(3-methyl-5-styrylisoxazol-4-yl)-4-arylthiophene-3-carboxamide synthon 3. Compound 3 is obtained by reaction of 2-(3-methyl-4-nitro-isoxazol-5-yl)-1-aryl-ethanone 1, N1-{3-methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl}-2- cyanoacetamide 2 and elemental sulfur in PEG-400. Isoxazolyl aryl thieno[2,3-d]pyrimidinones 4 have been obtained from compounds 3 by tandem N-acetylation and cyclodehydration with acetic anhydride. Compounds 3a-q and 4a-q have been characterized by IR, 1H and 13C NMR, and mass spectral data. The title compounds 4a-q have been evaluated for their antimicrobial activity. Compounds 4b, 4c, 4d, 4e, 4j, 4k, 4l and 4m exhibit significant antimicrobial activity, compared to that of standard drugs. |
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| Date |
2022-03-23T09:54:53Z
2022-03-23T09:54:53Z 2022-03 |
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| Type |
Article
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| Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59336 |
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| Language |
en
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| Publisher |
NIScPR-CSIR, India
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| Source |
IJC Vol.61(03) [March 2022]
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