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Design, synthesis and biological potential of some isoxazole and hydroxypyrimidine derivatives containing pyrido [2,3-d] pyrimidine nucleus via chalcone series

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Title Design, synthesis and biological potential of some isoxazole and hydroxypyrimidine derivatives containing pyrido [2,3-d] pyrimidine nucleus via chalcone series
 
Creator Tandel, Hemanshu T
Patel, Saurabh K
 
Subject Isoxazole
hydroxypyrimidine
synthesis
biological activity
 
Description 328-335
Synthesis of 4-(2,4-dimethoxy-6-(5-substitutedphenylisoxazol-3-yl) pyrido[2,3-d] pyrimidin-7-yl)morpholine has been carried out by reaction of (E)-3-(2,4-dimethoxy-7-morpholinopyrido[2,3-d]pyrimidin-6-yl)-1-substituted phenylprop-2-en-1-one with hydroxylamine hydrochloride analogue to get the compounds 8a-f and synthesis of 4-(2,4-dimethoxy-7-morpholinopyrido[2,3-d]pyrimidin-6-yl)-6-phenylpyrimidin-2-ol with urea to get various hydroxypyrimidine of the studied analogue to get the compounds 9a-f. Structures of all the newly synthesized compounds have been characterized by instrumental method. Representative compounds of the synthesized product series have been tested and evaluated as antimicrobial agents.
 
Date 2022-03-23T09:57:32Z
2022-03-23T09:57:32Z
2022-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59337
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(03) [March 2022]