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Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents

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Title Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents
 
Creator Jain, Surabhi
Sen, Dhrubo Jyoti
 
Subject Tuberculosis
imidazopyridine
ATP synthase
Lipinski rule of 5
ADME-T
 
Description 305-312
Tuberculosis is a global threat that is in urgent need for new molecules. In the same perspective, Imidazopyridine derivatives
have been synthesized against target ATP synthase. It is an important enzyme that provides energy for the cell to use through
the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most
organisms. Bedaquiline that primarily targets ATP now is most effective in treatment of tuberculosis. All synthesized molecules
pass Lipinski rule of 5 and are non-substrate of CYP450 enzymes. They didn’t portray significant anti-tubercular activity.
 
Date 2022-03-23T10:08:27Z
2022-03-23T10:08:27Z
2022-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59340
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(03) [March 2022]