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Synthesis, characterization and evaluation of thiopyrimidine derivatives as possible antimicrobial agents

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Title Synthesis, characterization and evaluation of thiopyrimidine derivatives as possible antimicrobial agents
 
Creator Kumar, J Bharath
Rajyalaxmi, I
Venkateshwarlu, K
Sirisha, K
 
Subject Chalcone
thiopyrimidine
S-alkylation
molecular properties
anti-microbial
 
Description 293-297
A series of new thiopyrimidine derivatives have been synthesized via the reaction of Chalcones 3a-c with thiourea to
give the corresponding pyrimidine thiones 4a-c. S-alkylation of pyrimidine thiones have resulted in novel 4,6-diaryl-2-alkyl
thiopyrimidine 5a-i derivatives. Molecular properties like number of hydrogen bond acceptors, number of hydrogen bond
donors, volume, polar surface area, molar refractivity, number of rotatable bonds and drug likeness for synthesized
compounds have been predicted by using different softwares such as Molinspiration, Molsoft and Chemsketch. The newly
synthesized 4,6-diaryl-2-alkyl thiopyrimidine derivatives 5a-i have been evaluated for their possible anti-microbial activity.
Compounds 5b, 5d and 5e have revealed significant activity against E. coli, P. aerugenosa (Gram +ve) and B. subtilis,
S. aureus (Gram −ve) species while compounds 5a, 5c, 5f-i are moderately active as compared to the standard drug
Ciprofloxacin. Compounds 5c and 5g show potent anti-fungal activity against Penicillium species amongst the series in
comparison to the standard Fluconazole.
 
Date 2022-03-23T10:20:30Z
2022-03-23T10:20:30Z
2022-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59342
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(03) [March 2022]