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Design and synthesis of novel s-triazine based coumarin, quinoline, morpholine and isoniazid derivatives and their antitubercular and antimicrobial evaluation

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Title Design and synthesis of novel s-triazine based coumarin, quinoline, morpholine and isoniazid derivatives and their antitubercular and antimicrobial evaluation
 
Creator Mahyavanshi, Jyotindra
Shrivastava, Vijay
Patel, Shraddha
Pandya, Jayesh
 
Subject s-Triazine
antimycobacterial activity
coumarin
quinoline
isoniazide
morpholine
 
Description 285-292
This study presents the synthesis of novel s-triazine derivatives. The synthetic route to final s-triazines consists of two nucleophilic substitution reactions of 4-hydroxy benzonitrile and 8-hydroxyquinoline or 8-hydroxy-7-methyl coumarin or isoniazid or morpholine with 2,4,6-trichloro-1,3,5-triazine resulting in 2,4-disubstituted-6-chloro-1,3,5-triazine derivatives to introduce the various amines functionality. The structures of the compounds have been elucidated with the aid of IR, 1H and 13C NMR, mass spectroscopy and elemental analysis. The title compounds have then been investigated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain by using BACTEC MGIT and Lowenstein-Jensen MIC method and antimicrobial evaluation.
 
Date 2022-03-23T10:23:24Z
2022-03-23T10:23:24Z
2022-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscair.res.in/handle/123456789/59343
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.61(03) [March 2022]