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Investigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adults

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Title Statement Investigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adults
 
Added Entry - Uncontrolled Name Aftabi, Younes
Amiri-Sadeghan, Amiri
Gilani, Neda
Bakhtiyari, Nasim
Ansarin, Atefeh
Sharifi, Akbar
Ansarin, Khalil
Khalili, Yeganeh
Seyedrezazadeh, Ensiyeh
 
Uncontrolled Index Term AhR gene; Lung diseases; Genetic association; rs2066853; Polymorphism
 
Summary, etc. Aryl hydrocarbon Receptor (AhR) is a ligand-activated transcription factor with an important role in lung health. The association of AhR polymorphisms with asthma severity has not been yet investigated. We analyzed the association of G1661A, the most prevalent polymorphism of AhR, with the asthma stages in a population-based study including 555 asthmatics (Intermittent: 93, Mild: 240, Moderate: 158, and Severe: 64). The SNP was genotyped using allele-specific PCR. Obtained data were analyzed using the Generalized-Ordered Logit Estimates. Genotypes GA (OR: 0.53, CI: 0.32-0.90, P=0.019) and AA (OR: 0.22, CI: 0.06-0.76, P=0.017) were associated with decreased risk of Severe, Moderate, Mild vs. Intermittent stage; and Severe, Moderate, vs. Mild, Intermittent stages respectively. However, Genotype GA (OR: 1.90, CI: 1.05-3.44, P=0.033), dominant model GA+AA (OR: 2.04, CI: 1.17-3.57, P=0.012), and allele A (OR: 1.68, CI: 1.06-2.66, P=0.027) were associated with increased risk of Severe stage vs. Moderate, Mild, Intermittent stages. Also, male sex and higher age were associated with an increased odds ratio for severe asthma. Furthermore, significant associations with asthma stages were found for the interactions of the SNP and sex, smoking, and alcohol consumption. In conclusion, we revealed that the mutant allele of AhR-G1661A may interact with independent variables and act as a protective factor against lower stages of asthma but it may increase the risk of severe asthma.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2022-03-23 16:17:27
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/59000
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 59 (3) [March 2022]
 
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