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Protective effect of huperzine A on phenytoin induced cognition impairment: Behavioral and biochemical study

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Title Protective effect of huperzine A on phenytoin induced cognition impairment: Behavioral and biochemical study
 
Creator Dubey (Upadhyay), Shagun
 
Subject Acetylcholinesterase (AChE)
Butyrylcholinesterase (BChE)
Cerebrum
Neurprotection
Nootropic
 
Description 205-213
Phenytoin, a drug of choice for Epilepsy is also known for its adverse effects. The most common adverse effect due to
phenytoin is cognition impairment. Cognition impairment is a serious problem in society as it debars the person's social life.
Thus to overcome such a problem demand for a solution arises. Huperzine, sesquiterpene alkaloids having immense
neuroprotective properties. Thus in this study, it was aimed to evaluate the effectiveness of huperzine on Phenytoin- induced
Cognition Impairment. The protective effect of huperzine on phenytoin-induced cognition impairment was evaluated in rats.
The effect of Huperzine on phenytoin-induced cognitive impairment was evaluated by behavioral, biochemical, and
histopathological studies. The co-administration of huperzine with phenytoin showed significant results. The treatment of
Huperzine with phenytoin resulted in significant improvement in learning and memory. The oxidative stress induced by
Phenytoin was reversed by huperzine. A significant decrease in cholinesterase activity was also observed. The histopathology
showed damaged neuronal cells in periventricular regions and cortex due to phenytoin which was altered by Huperzine. Thus,
the present study demonstrates the protective effect of huperzine on phenytoin-induced cognition impairment.
 
Date 2022-03-25T05:52:05Z
2022-03-25T05:52:05Z
2022-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59369
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(2) [February 2022]