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Evaluation of trans-cinnamaldehyde as an anti-hyperglycemic compound through inhibition of α- amylase

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Title Evaluation of trans-cinnamaldehyde as an anti-hyperglycemic compound through inhibition of α- amylase
 
Creator Anjali
Sadaf, Ayesha
Khare, SK
 
Subject Amylase inhibitor
Hyperglycemia
Inhibition kinetics
Trans-cinnamaldehyde
α-amylase
 
Description 183-188
The present study aims to evaluate the effectiveness of Cinnamon (Cinnamomum verum) derive bioactive compound viz.trans-cinnamaldehyde, cinnamyl alcohol, and cinnamic acid on inhibition of Bacillus licheniformis α-amylase (BLA) and pancreatic porcine α-amylase (PPA) activity. The inhibition extent of each of the compounds was determined along with their inhibition kinetics and compared with standard inhibitor-acarbose (Synthetic anti-diabetic agent). The IC50 values for trans-cinnamaldehyde with respect to BLA and PPAwere observed to 5.38 μg mL−1 and 3.76 μg mL−1, respectively. The IC50value of acarbose was estimated to be 6.2 μg mL−1 for both the amylases. The maximum percent enzyme inhibition of 75.8 (at 10.75 μg mL−1) and 71.6 (5.38 μg mL−1) were observed in case of BLA and PPA, respectively, using trans-cinnamaldehyde. Cinnamyl alcohol and cinnamic acid on the other hand were observed to show no specific inhibitory effect on the both the α-amylases even at high concentrations. Catalytic efficiency (Vmax/Km) of both the amylases was observed to decrease significantly in presence of trans-cinnamaldehyde compared to acarbose. Overall, trans-cinnamaldehyde was observed as a better inhibitor of α-amylase compared to known synthetic inhibitor-acarbose. Thus, trans-cinnamaldehyde could effectively be used for controlling hyperglycemia and diabetes mellitus.
 
Date 2022-03-25T06:07:45Z
2022-03-25T06:07:45Z
2022-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59372
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(2) [February 2022]