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Anti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial target

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Title Anti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial target
 
Creator Sharma, Venu
Sharma, Supriya
Mehra, Rukmankesh
Kapoor, Kamal K
Dhar, Manoj K
Kaul, Sanjana
 
Subject Andrographis paniculata
Antimicrobial activity
Labdane diterpenes
Molecular modeling
Semi-synthetic derivative
 
Description 157-164
Natural products and their semi synthesized molecules have been used as efficient antibiotics since a long time. The
present global health scenario has raised the demand for novel antimicrobial agents and drug targets that are effective
against drug resistant pathogens, emerging infections etc. The current study has promoted the antibacterial activity of the
glucoside labdane ‘neoandrographolide’, isolated from the methanolic extract of the medicinal plant Andrographis
paniculata. Further modification at its glucoside hydroxyl groups to generate ester and acetonide derivatives was done and
the antibacterial potential of these compounds was screened against common bacterial pathogens. Among various
derivatives, 4,6-O-(4-methoxybenzylidene) neoandrographolide exhibited promising results. In addition, molecular
modeling study of the active compound was also explored to identify its probable binding mode on the bacterial target. The
present study reported antibacterial activity of neoandrographolide derivatives for first time and also the bioactive molecule,
4,6-O-(4-methoxybenzylidene) neoandrographolide was examined as a potent antibacterial agent against different strains.
 
Date 2022-03-25T06:19:58Z
2022-03-25T06:19:58Z
2022-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59375
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(2) [February 2022]