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The effect of L-theanine on the oxidant-antioxidant balance in serum and lung tissue in experimentally induced sepsis in rats

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Title The effect of L-theanine on the oxidant-antioxidant balance in serum and lung tissue in experimentally induced sepsis in rats
 
Creator Malkoç, Meltem
Patan, Huriye
Yaman, Serap Özer
Türedi, Süleyman
Ersöz, Şafak
Kural, Birgül Vanizor
Örem, Asım
 
Subject Cecal ligation and puncture
L-theanine (γ-glutamylethylamide)
Sepsis
Oxidative stress
Lung injury
 
Description 139-147
Sepsis induces lung injury and respiratory distress syndrome and is therefore potentially fatal. L-theanine (LT), an amino acid found in tea, is a bioactive compound with an important antioxidant, anti-inflammatory, and antifibrotic properties. The purpose of this study was to evaluates whether, LT exhibits protective effects against lung tissue damage by determining its effect on oxidative stress, inflammation and mineral levels in an experimental model of cecal ligation and perforation (CLP)-induced sepsis in rats. Rats were randomly divided into three groups (n=6): sham, CLP, and CLP+LT. LT was administered intraperitoneally (750 mg/kg) in two equal doses immediately and 12 h after surgery. Malondialdehyde (MDA), advanced protein oxidation product (AOPP), myeloperoxidase (MPO), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and ischemia modified albumin (IMA) values were determined spectrophotometrically. Serum elements (Na, K, Mg, Ca, and Fe), albumin, glucose, triglyceride, and lactate levels were determined using an autoanalyzer. Lung tissues were also examined histopathologically. Treatment of septic rats with LT significantly reduced oxidative stress and inflammation in lung tissues and serum. LT also increased albumin and Na levels and reduced triglyceride levels in serum. In conclusion, LT treatment may exhibit a preventive effect against sepsis-induced lung injury by reducing oxidative stress and inflammation, and by regulating osmotic balance.
 
Date 2022-03-25T06:25:01Z
2022-03-25T06:25:01Z
2022-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59377
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(2) [February 2022]