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Investigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adults

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Title Investigating possible effects of aryl hydrocarbon receptor G1661A polymorphism on asthma severity in adults
 
Creator Aftabi, Younes
Amiri-Sadeghan, Amir
Gilani, Neda
Bakhtiyari, Nasim
Ansarin, Atefeh
Sharifi, Akbar
Ansarin, Khalil
Khalili, Yeganeh
Seyedrezazadeh, Ensiyeh
 
Subject AhR gene
Lung diseases
Genetic association
rs2066853
Polymorphism
 
Description 311-319
Aryl hydrocarbon Receptor (AhR) is a ligand-activated transcription factor with an important role in lung health. The
association of AhR polymorphisms with asthma severity has not been yet investigated. We analyzed the association of
G1661A, the most prevalent polymorphism of AhR, with the asthma stages in a population-based study including 555
asthmatics (Intermittent: 93, Mild: 240, Moderate: 158, and Severe: 64). The SNP was genotyped using allele-specific PCR.
Obtained data were analyzed using the Generalized-Ordered Logit Estimates. Genotypes GA (OR: 0.53, CI: 0.32-0.90,
P=0.019) and AA (OR: 0.22, CI: 0.06-0.76, P=0.017) were associated with decreased risk of Severe, Moderate, Mild vs.
Intermittent stage; and Severe, Moderate, vs. Mild, Intermittent stages respectively. However, Genotype GA (OR: 1.90, CI:
1.05-3.44, P=0.033), dominant model GA+AA (OR: 2.04, CI: 1.17-3.57, P=0.012), and allele A (OR: 1.68, CI: 1.06-2.66,
P=0.027) were associated with increased risk of Severe stage vs. Moderate, Mild, Intermittent stages. Also, male sex and
higher age were associated with an increased odds ratio for severe asthma. Furthermore, significant associations with asthma
stages were found for the interactions of the SNP and sex, smoking, and alcohol consumption. In conclusion, we revealed
that the mutant allele of AhR-G1661A may interact with independent variables and act as a protective factor against lower
stages of asthma but it may increase the risk of severe asthma.
 
Date 2022-03-25T11:42:03Z
2022-03-25T11:42:03Z
2022-03
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59385
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(3) [March 2022]