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Blood formed elements of the women with uterine tumors as one of the criterion for assessment of severity of the pathology

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Title Blood formed elements of the women with uterine tumors as one of the criterion for assessment of severity of the pathology
 
Creator Kotrikadze, Nanuli
Tuphinashvili, Tamar
Alibegashvili, Manana
Ramishvili, Liana
Nakashidze, Irina
Artmeladze, Mukhamed
Gordeziani, Manana
Zibzibadze, Maia
Khazaradze, Ana
Sepiashvili, Bela
Ahmad, Sarfraz
 
Subject Blood Formed Elements
Hormonal Imbalance
Menopausal Women
Morphological Characteristics
Pathological Assessments
Transmission Electron Microscopy
Uterine Cancer
 
Description 268-275
The indicators for structural analysis of blood formed elements are prominent in the assessment of pathologies, diagnostics
and the degree. Therefore, we aimed to evaluate the ongoing alterations that reflect on the structural characteristics of blood
formed elements based on the hormonal imbalance among menopausal women with uterine tumors. Blood samples from the
women with benign (n=20), malignant (n=20) uterine tumors, and healthy menopausal women (control, n=20) were used.
Enzyme-linked Immunosorbent assay (ELISA) kits were used for the quantitative determination of hormones. The blood formed
elements ultrastructure observations were conducted using transmission electron microscope. Compared to control (33.8±0.7 pg/mL),
estradiol level was higher in benign (45.7±0.9 pg/mL) and malignant (70.7±3.7 pg/mL) cases (P< 0.001). Similar pattern was
noted in testosterone levels [control=0.38±0.03 ng/mL, benign=0.55±0.04 ng/mL (P< 0.01), malignant=1.56±0.14 ng/mL
(P< 0.001)] was higher in malignant cases. In contrast, progesterone levels were decreased in the disease cases
[control=0.93±0.05 ng/mL, benign=0.44±0.003 ng/mL, malignant=0.31±0.02 ng/ml (P< 0.001)]. Assessments of the
morphologic structure of erythrocytes revealed pathological forms of erythrocytes (poikilocytosis) in case of benign, as well as in
malignant tumors. particularly target cells (codocytes), hamlet cells, teardrop cells (dacrocytes), sickle cell (drepanocytes)
erythrocytes. Using ELISA and transmission electron microscopy our results demonstrate that in case of malignant uterine tumor
quantitative/structural changes occur in blood formed elements indicating ongoing alterations in hormonal imbalance. Assessing
these changes in structural characteristics would be useful in examining uterine pathologies and subsequent treatment plans.
 
Date 2022-03-25T11:51:05Z
2022-03-25T11:51:05Z
2022-03
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/59388
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.59(3) [March 2022]